Arx Polyalanine Expansion in Mice Leads to Reduced Pancreatic α-Cell Specification and Increased α-Cell Death

Crystal L. Wilcox; Natalie A. Terry; Catherine Lee May

doi:10.1371/journal.pone.0078741

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Peer-reviewed

Research Article

Arx Polyalanine Expansion in Mice Leads to Reduced Pancreatic α-Cell Specification and Increased α-Cell Death

Crystal L. Wilcox,

Affiliation Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Natalie A. Terry,

Affiliation Department of Pediatrics, Division of Gastroenterology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Catherine Lee May

* E-mail: catheril@mail.med.upenn.edu

Affiliations Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

Arx Polyalanine Expansion in Mice Leads to Reduced Pancreatic α-Cell Specification and Increased α-Cell Death

Crystal L. Wilcox,
Natalie A. Terry,
Catherine Lee May

Published: November 13, 2013
https://doi.org/10.1371/journal.pone.0078741

About the Authors

Crystal L. Wilcox

Affiliation Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Natalie A. Terry

Affiliation Department of Pediatrics, Division of Gastroenterology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Catherine Lee May

* E-mail: catheril@mail.med.upenn.edu

Affiliations Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CW NT CLM. Performed the experiments: CW. Analyzed the data: CW NT. Contributed reagents/materials/analysis tools: CW NT. Wrote the paper: CW NT CLM.

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