About the Authors

Gines Escolar

Contributed equally to this work with: Gines Escolar, Victor Fernandez-Gallego

gescolar@clinic.ub.es

Affiliation Department of Hemotherapy-Hemostasis, Hospital Clinic, Centre de Diagnostic Biomedic, Institut d'Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain

Victor Fernandez-Gallego

Contributed equally to this work with: Gines Escolar, Victor Fernandez-Gallego

Affiliation Bristol-Myers Squibb, Madrid, Spain

Eduardo Arellano-Rodrigo

Affiliation Department of Hemotherapy-Hemostasis, Hospital Clinic, Centre de Diagnostic Biomedic, Institut d'Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain

Jaume Roquer

Affiliation Department of Neurology, Hospital Universitari del Mar, Parc de Salut Mar, Barcelona, Spain

Joan Carles Reverter

Affiliation Department of Hemotherapy-Hemostasis, Hospital Clinic, Centre de Diagnostic Biomedic, Institut d'Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain

Victoria Veronica Sanz

Affiliation Department of Hemotherapy-Hemostasis, Hospital Clinic, Centre de Diagnostic Biomedic, Institut d'Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain

Patricia Molina

Affiliation Department of Hemotherapy-Hemostasis, Hospital Clinic, Centre de Diagnostic Biomedic, Institut d'Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain

Irene Lopez-Vilchez

Affiliation Department of Hemotherapy-Hemostasis, Hospital Clinic, Centre de Diagnostic Biomedic, Institut d'Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain

Maribel Diaz-Ricart

Affiliation Department of Hemotherapy-Hemostasis, Hospital Clinic, Centre de Diagnostic Biomedic, Institut d'Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain

Ana Maria Galan

Affiliation Department of Hemotherapy-Hemostasis, Hospital Clinic, Centre de Diagnostic Biomedic, Institut d'Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain

Competing Interests

This work was partially supported by an investigator sponsored award from BMS-Pfizer. Fernandez-Gallego V is employed by Bristol-Myers Squibb, the producer of Apixaban. Gines Escolar has received honoraria/consultant fees from Bayer, BMS, Boehringer Ingelheim, CSL Behring and NovoNordisk. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: GE VFG MDR AMG. Performed the experiments: EAR JR JCR VVS PM ILV. Analyzed the data: GE VFG EAR JR JCR VVS PM ILV MDR AMG. Wrote the paper: GE VFG EAR JR JCR VVS PM ILV MDR AMG.