About the Authors
- Silvia La Monica
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Affiliation Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy
- Cristina Caffarra
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Affiliation Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy
- Francesca Saccani
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Affiliation Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy
- Elena Galvani
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Affiliations Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy, Department Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
- Maricla Galetti
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Affiliations Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy, Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy
- Claudia Fumarola
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Affiliation Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy
- Mara Bonelli
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Affiliation Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy
- Andrea Cavazzoni
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Affiliation Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy
- Daniele Cretella
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Affiliation Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy
- Rita Sirangelo
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Affiliation Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy
- Rita Gatti
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Affiliation Department of Biotechnology, Biomedical and Translational Sciences, University of Parma, Parma, Italy
- Marcello Tiseo
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Affiliation Division of Medical Oncology, University Hospital of Parma, Parma, Italy
- Andrea Ardizzoni
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Affiliation Division of Medical Oncology, University Hospital of Parma, Parma, Italy
- Elisa Giovannetti
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* E-mail: roberta.alfieri@unipr.it (RA); e.giovannetti@vumc.nl (E. Giovannetti)
Affiliation Department Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
- Pier Giorgio Petronini
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Affiliation Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy
- Roberta R. Alfieri
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* E-mail: roberta.alfieri@unipr.it (RA); e.giovannetti@vumc.nl (E. Giovannetti)
Affiliation Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy
Competing Interests
This work was supported by AstraZeneca. The Gefitinib used in this study is marketed by AstraZeneca and was provided by them. NVP-BEZ235 was provided by Novartis Institutes for BioMedical Research. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Author Contributions
Conceived and designed the experiments: SL RRA PGP. Performed the experiments: SL CC FS E. Galvani MG CF MB RS. Analyzed the data: E. Giovannetti AA RRA. Contributed reagents/materials/analysis tools: RG DC AC. Wrote the manuscript: RRA SL E. Giovannetti. Critically revision of the manuscript: PGP AA MT.