About the Authors

Shanrong Zhao

shanrong_zhao@yahoo.com (SZ); xliu3@its.jnj.com (XL)

Affiliation Systems Pharmacology and Biomarkers, Janssen Research & Development, LLC, San Diego, California, United States of America

Wai-Ping Fung-Leung

Affiliation Immunology, Janssen Research & Development, LLC, San Diego, California, United States of America

Anton Bittner

Affiliation C.R.E.A.Te Integrative Systems Biology, Janssen Research & Development, LLC, San Diego, California, United States of America

Karen Ngo

Affiliation Immunology, Janssen Research & Development, LLC, San Diego, California, United States of America

Xuejun Liu

shanrong_zhao@yahoo.com (SZ); xliu3@its.jnj.com (XL)

Affiliation Systems Pharmacology and Biomarkers, Janssen Research & Development, LLC, San Diego, California, United States of America

Competing Interests

The authors have declared the following interests: Authors Shanrong Zhao, Wai-Ping Fung-Leung, Anton Bittner, Karen Ngo, and Xuejun Liu are employed by Janssen Research & Development, LLC. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SZ WL. Analyzed the data: SZ XL. Wrote the paper: SZ WL XL AB. Prepared all RNA samples for RNA-Seq and microarray study: KN. Performed the microarray: AB.