About the Authors

Kengo Yamawaki

Contributed equally to this work with: Kengo Yamawaki, Shinobu Ueda

kengo.yamawaki@kyowa-kirin.co.jp (KY); ktomizuka@kyowa-kirin-ca.com (KT)

Affiliation Biologics Research Laboratories, Kyowa Hakko Kirin Co., Ltd, Machida-shi, Tokyo, Japan

Shinobu Ueda

Contributed equally to this work with: Kengo Yamawaki, Shinobu Ueda

Affiliation Comprehensive Research Organization, Institute for Innovation Design, Waseda University, Shinjuku-ku, Tokyo, Japan

Tsutomu Okada

Affiliation Biologics Research Laboratories, Kyowa Hakko Kirin Co., Ltd, Machida-shi, Tokyo, Japan

Takeshi Oshima

Affiliation Biologics Research Laboratories, Kyowa Hakko Kirin Co., Ltd, Machida-shi, Tokyo, Japan

Makoto Kakitani

Affiliation Biologics Research Laboratories, Kyowa Hakko Kirin Co., Ltd, Machida-shi, Tokyo, Japan

Takashi Kato

Affiliation Department of Biology, School of Education, Waseda University, Shinjuku-ku, Tokyo, Japan

Kazuma Tomizuka

kengo.yamawaki@kyowa-kirin.co.jp (KY); ktomizuka@kyowa-kirin-ca.com (KT)

Affiliation Kyowa Hakko Kirin California, Inc., La Jolla, San Diego, California, United States of America

Competing Interests

The authors have the following interests. Financial support for this study was provided by Kyowa-Hakko Kirin Co. Ltd., the employer of Kengo Yamawaki, Tsutomu Okada, Takeshi Oshima, Makoto Kakitani and Kazuma Tomizuka. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: SU MK TK KT. Performed the experiments: KY SU T. Okada T. Oshima. Analyzed the data: KY SU T. Okada T. Oshima MK TK KT. Contributed reagents/materials/analysis tools: KY SU T. Okada T. Oshima MK TK KT. Wrote the manuscript: KY SU.