Rapid Inhibition of Pyruvate Dehydrogenase: An Initiating Event in High Dietary Fat-Induced Loss of Metabolic Flexibility in the Heart

Clair Crewe; Michael Kinter; Luke I. Szweda

doi:10.1371/journal.pone.0077280

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Peer-reviewed

Research Article

Rapid Inhibition of Pyruvate Dehydrogenase: An Initiating Event in High Dietary Fat-Induced Loss of Metabolic Flexibility in the Heart

Clair Crewe,

Affiliations Free Radical Biology and Aging Research Program Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, United States of America
⨯
Michael Kinter,

Affiliations Free Radical Biology and Aging Research Program Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Geriatric Medicine, Reynolds Center on Aging, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, United States of America
⨯
Luke I. Szweda

* E-mail: Luke-Szweda@omrf.org

Affiliations Free Radical Biology and Aging Research Program Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, United States of America, Department of Geriatric Medicine, Reynolds Center on Aging, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, United States of America
⨯

Rapid Inhibition of Pyruvate Dehydrogenase: An Initiating Event in High Dietary Fat-Induced Loss of Metabolic Flexibility in the Heart

Clair Crewe,
Michael Kinter,
Luke I. Szweda

Published: October 7, 2013
https://doi.org/10.1371/journal.pone.0077280

About the Authors

Clair Crewe

Michael Kinter

Affiliations Free Radical Biology and Aging Research Program Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Geriatric Medicine, Reynolds Center on Aging, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, United States of America

Luke I. Szweda

* E-mail: Luke-Szweda@omrf.org

Affiliations Free Radical Biology and Aging Research Program Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, United States of America, Department of Geriatric Medicine, Reynolds Center on Aging, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CC MK LS. Performed the experiments: CC MK LS. Analyzed the data: CC MK LS. Contributed reagents/materials/analysis tools: MK LS. Wrote the manuscript: CC MK LS.

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Diet
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Fats
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Mitochondria
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Pyruvate
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Glucose metabolism
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Heart
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Fatty acids
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Trophic interactions
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