About the Authors

Orr Hadass

Contributed equally to this work with: Orr Hadass, Brittany N. Tomlinson

Affiliations Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, United States of America, Center for Translational Neuroscience, University of Missouri School of Medicine, Columbia, Missouri, United States of America, MS in Pathology Program, University of Missouri Graduate School, Columbia, Missouri, United States of America

Brittany N. Tomlinson

Contributed equally to this work with: Orr Hadass, Brittany N. Tomlinson

Affiliations Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, United States of America, Center for Translational Neuroscience, University of Missouri School of Medicine, Columbia, Missouri, United States of America, MS in Pathology Program, University of Missouri Graduate School, Columbia, Missouri, United States of America

Major Gooyit

Affiliation Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America

Shanyan Chen

Affiliations Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, United States of America, Center for Translational Neuroscience, University of Missouri School of Medicine, Columbia, Missouri, United States of America, Interdisciplinary Neuroscience Program, University of Missouri Graduate School, Columbia, Missouri, United States of America

Justin J. Purdy

Affiliations Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, United States of America, Center for Translational Neuroscience, University of Missouri School of Medicine, Columbia, Missouri, United States of America

Jennifer M. Walker

Affiliation Department of Psychological Sciences, University of Missouri, Columbia, Missouri, United States of America

Chunyang Zhang

† Deceased.

Affiliations Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, United States of America, Center for Translational Neuroscience, University of Missouri School of Medicine, Columbia, Missouri, United States of America

Andrew B. Giritharan

Affiliations Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, United States of America, Center for Translational Neuroscience, University of Missouri School of Medicine, Columbia, Missouri, United States of America

Whitley Purnell

Affiliations Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, United States of America, Center for Translational Neuroscience, University of Missouri School of Medicine, Columbia, Missouri, United States of America

Christopher R. Robinson II

Affiliations Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, United States of America, Center for Translational Neuroscience, University of Missouri School of Medicine, Columbia, Missouri, United States of America

Dmitriy Shin

Affiliation Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, United States of America

Valerie A. Schroeder

Affiliation Freimann Life Sciences Center and Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America

Mark A. Suckow

Affiliation Freimann Life Sciences Center and Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America

Agnes Simonyi

Affiliations Department of Biochemistry, University of Missouri School of Medicine, Columbia, Missouri, United States of America, Center for Translational Neuroscience, University of Missouri School of Medicine, Columbia, Missouri, United States of America

Grace Y. Sun

Affiliations Department of Biochemistry, University of Missouri School of Medicine, Columbia, Missouri, United States of America, Center for Translational Neuroscience, University of Missouri School of Medicine, Columbia, Missouri, United States of America

Shahriar Mobashery

Affiliation Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America

Jiankun Cui

Affiliations Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, United States of America, Center for Translational Neuroscience, University of Missouri School of Medicine, Columbia, Missouri, United States of America

Mayland Chang

guze@health.missouri.edu (ZG); mchang@nd.edu

Affiliation Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America

Zezong Gu

guze@health.missouri.edu (ZG); mchang@nd.edu

Affiliations Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, United States of America, Center for Translational Neuroscience, University of Missouri School of Medicine, Columbia, Missouri, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZG JC. Performed the experiments: OH BNT SC JP CZ JMW AG WP CRR AS JC. Analyzed the data: OH BNT SC DS AS SM JC MC ZG. Contributed reagents/materials/analysis tools: MG SM MC. Wrote the paper: OH BNT MC ZG. Performed the PK study: MG VAS MAS. Made significant input for the manuscript: AS GYS SM JC.