About the Authors

Erin Hertlein

Affiliation Department of Internal Medicine, Division of Hematology, Comprehensive Cancer Center at The Ohio State University, Columbus, Ohio, United States of America

Kyle A. Beckwith

Affiliation Department of Internal Medicine, Division of Hematology, Comprehensive Cancer Center at The Ohio State University, Columbus, Ohio, United States of America

Gerard Lozanski

Affiliation Department of Pathology, the Ohio State University, Columbus, Ohio, United States of America

Timothy L. Chen

Affiliation Department of Internal Medicine, Division of Hematology, Comprehensive Cancer Center at The Ohio State University, Columbus, Ohio, United States of America

William H. Towns

Affiliation Department of Internal Medicine, Division of Hematology, Comprehensive Cancer Center at The Ohio State University, Columbus, Ohio, United States of America

Amy J. Johnson

Affiliation Department of Internal Medicine, Division of Hematology, Comprehensive Cancer Center at The Ohio State University, Columbus, Ohio, United States of America

Amy Lehman

Affiliation Center for Biostatistics, the Ohio State University, Columbus, Ohio, United States of America

Amy S. Ruppert

Affiliation Department of Internal Medicine, Division of Hematology, Comprehensive Cancer Center at The Ohio State University, Columbus, Ohio, United States of America

Brad Bolon

Affiliation Department of Veterinary Biosciences and the Comparative Pathology and Mouse Phenotyping Shared Resource, the Ohio State University, Columbus, Ohio, United States of America

Leslie Andritsos

Affiliation Department of Internal Medicine, Division of Hematology, Comprehensive Cancer Center at The Ohio State University, Columbus, Ohio, United States of America

Arletta Lozanski

Affiliation Department of Internal Medicine, Division of Hematology, Comprehensive Cancer Center at The Ohio State University, Columbus, Ohio, United States of America

Laura Rassenti

Affiliation Moores University of California-San Diego Cancer Center, University of California San Diego, California, United States of America

Weiqiang Zhao

Affiliation Department of Pathology, the Ohio State University, Columbus, Ohio, United States of America

Tiina M. Jarvinen

Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Cancer Genetics, Comprehensive Cancer Center at the Ohio State University, Columbus, Ohio, United States of America

Leigha Senter

Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Cancer Genetics, Comprehensive Cancer Center at the Ohio State University, Columbus, Ohio, United States of America

Carlo M. Croce

Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Cancer Genetics, Comprehensive Cancer Center at the Ohio State University, Columbus, Ohio, United States of America

David E. Symer

Affiliations Department of Internal Medicine, Division of Hematology, Comprehensive Cancer Center at The Ohio State University, Columbus, Ohio, United States of America, Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Cancer Genetics, Comprehensive Cancer Center at the Ohio State University, Columbus, Ohio, United States of America

Albert de la Chapelle

Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Cancer Genetics, Comprehensive Cancer Center at the Ohio State University, Columbus, Ohio, United States of America

Nyla A. Heerema

Affiliation Department of Pathology, the Ohio State University, Columbus, Ohio, United States of America

John C. Byrd

* Email: john.byrd@osumc.edu

Affiliation Department of Internal Medicine, Division of Hematology, Comprehensive Cancer Center at The Ohio State University, Columbus, Ohio, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EH AJJ NAH GL DES ADLC JCB. Performed the experiments: EH KAB TLC WHT A. Lehman ASR BB A. Lozanski LR WZ. Analyzed the data: EH KAB A. Lehman ASR BB LR. Contributed reagents/materials/analysis tools: A. Lehman ASR LA LS. Wrote the manuscript: EH JCB. reviewed drafts and approved the final version of the manuscript; EH KAB GL TLC WHT AJJ A. Lehamn ASR BB LA A. Lozanski LR WZ TMJ LS CMC DES ADLC NAH JCB.