About the Authors
- David C. Pryde
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Affiliation Pfizer Worldwide Medicinal Chemistry, Cambridge, United Kingdom
- Lyn H. Jones
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Affiliation Pfizer Worldwide Medicinal Chemistry, BioTherapeutics Chemistry, Cambridge, Massachusetts, United States of America
- David P. Gervais
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Current address: Health Protection Agency, Process and Analytical Development Group, Porton Down, Salisbury, United Kingdom
Affiliation Pfizer Vaccine Research, La Jolla, California, United States of America
- David R. Stead
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Affiliation Pfizer Vaccine Research, La Jolla, California, United States of America
- David C. Blakemore
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Affiliation Pfizer Worldwide Medicinal Chemistry, Cambridge, United Kingdom
- Matthew D. Selby
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Current address: UCB Celltech, Slough, Berkshire, United Kingdom
Affiliation Pfizer Worldwide Medicinal Chemistry, BioTherapeutics Chemistry, Cambridge, Massachusetts, United States of America
- Alan D. Brown
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Affiliation Pfizer Worldwide Medicinal Chemistry, Cambridge, United Kingdom
- Jotham W. Coe
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Affiliation Pfizer Worldwide Medicinal Chemistry, Groton, Connecticut, United States of America
- Matthew Badland
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Affiliation Pfizer Chemical Research and Development, Sandwich, United Kingdom
- David M. Beal
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Current address: School of Biosciences, University of Kent, Canterbury, Kent, United Kingdom
Affiliation Pfizer Worldwide Medicinal Chemistry, BioTherapeutics Chemistry, Cambridge, Massachusetts, United States of America
- Rebecca Glen
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Affiliation Peakdale Molecular Ltd, Chapel-en-le-Frith, United Kingdom
- Yvonne Wharton
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Current address: C-Tech Innovation Ltd, Chester, United Kingdom
Affiliation Peakdale Molecular Ltd, Chapel-en-le-Frith, United Kingdom
- Gavin J. Miller
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Current address: School of Chemistry, the University of Manchester, Manchester, United Kingdom
Affiliation Peakdale Molecular Ltd, Chapel-en-le-Frith, United Kingdom
- Phil White
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Affiliation Pfizer Vaccine Research, La Jolla, California, United States of America
- Ningli Zhang
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Affiliation Pfizer Vaccine Research, Ottawa, Ontario, Canada
- Michelle Benoit
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Affiliation Pfizer Vaccine Research, Ottawa, Ontario, Canada
- Karen Robertson
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Affiliation Pfizer Vaccine Research, Ottawa, Ontario, Canada
- James R. Merson
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Affiliation Pfizer Vaccine Research, La Jolla, California, United States of America
- Heather L. Davis
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Affiliation Pfizer Vaccine Research, Ottawa, Ontario, Canada
- Michael J. McCluskie
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* E-mail: michael.mccluskie@pfizer.com
Affiliation Pfizer Vaccine Research, Ottawa, Ontario, Canada
Competing Interests
All authors were either under paid employment or consultancy agreement with Pfizer at the time of these studies. Co-authors YW, GM, and RG were employed by Peakdale Molecular Ltd at the time of these studies. Pfizer is pursuing patents and product development on compounds that are mentioned in this paper. There are no marketed products to declare. DP, LJ, DG, DS, D. Blakemore, MS, AB, JC, M. Badland, D. Beal, PW, NZ, M. Benoit, KR, JM, HD and MM all hold shares or share options of Pfizer. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: DP LJ DG DS D. Blakemore MS AB JC M. Badland D. Beal RG YW GM PW NZ M. Benoit KR JM HD MM. Performed the experiments: DP LJ DG DS D. Blakemore MS M. Badland D. Beal RG YW GM NZ M. Benoit KR. Analyzed the data: DP LJ DG DS D. Blakemore MS M. Badland D. Beal PW NZ M. Benoit KR JM HD MM. Contributed reagents/materials/analysis tools: DP LJ DG DS D. Blakemore MS M. Badland D. Beal RG YW GM NZ M. Benoit KR. Wrote the manuscript: DP LJ DG DS D. Blakemore MS AB JC M. Badland D. Beal RG YW GM PW NZ M. Benoit KR JM HD MM.