Sox2 Expression Is Regulated by a Negative Feedback Loop in Embryonic Stem Cells That Involves AKT Signaling and FoxO1

Briana D. Ormsbee Golden; Erin L. Wuebben; Angie Rizzino

doi:10.1371/journal.pone.0076345

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Peer-reviewed

Research Article

Sox2 Expression Is Regulated by a Negative Feedback Loop in Embryonic Stem Cells That Involves AKT Signaling and FoxO1

Briana D. Ormsbee Golden ,

Contributed equally to this work with: Briana D. Ormsbee Golden, Erin L. Wuebben

Affiliation Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Erin L. Wuebben ,

Contributed equally to this work with: Briana D. Ormsbee Golden, Erin L. Wuebben

Affiliation Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Angie Rizzino

* E-mail: arizzino@unmc.edu

Affiliation Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯

Sox2 Expression Is Regulated by a Negative Feedback Loop in Embryonic Stem Cells That Involves AKT Signaling and FoxO1

Briana D. Ormsbee Golden,
Erin L. Wuebben,
Angie Rizzino

Published: October 8, 2013
https://doi.org/10.1371/journal.pone.0076345

About the Authors

Briana D. Ormsbee Golden

Contributed equally to this work with: Briana D. Ormsbee Golden, Erin L. Wuebben

Affiliation Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

Erin L. Wuebben

Contributed equally to this work with: Briana D. Ormsbee Golden, Erin L. Wuebben

Affiliation Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

Angie Rizzino

* E-mail: arizzino@unmc.edu

Affiliation Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BOG EW AR. Performed the experiments: BOG EW. Analyzed the data: BOG EW AR. Contributed reagents/materials/analysis tools: AR. Wrote the paper: BOG EW AR.

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Signal inhibition
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Immunoprecipitation
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Messenger RNA
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Transcription factors
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Gene expression
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Protein extraction
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Pluripotency
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Transcriptional control
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