Methylcobalamin Facilitates Collateral Sprouting of Donor Axons and Innervation of Recipient Muscle in End-to-Side Neurorrhaphy in Rats

Wen-Chieh Liao; Yueh-Jan Wang; Min-Chuan Huang; Guo-Fang Tseng

doi:10.1371/journal.pone.0076302

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Peer-reviewed

Research Article

Methylcobalamin Facilitates Collateral Sprouting of Donor Axons and Innervation of Recipient Muscle in End-to-Side Neurorrhaphy in Rats

Wen-Chieh Liao,

Affiliation Department of Anatomy, Faculty of Medicine, Chung Shan Medical University and Department of Pediatrics, Chung Shan Medical University Hospital, Taichung City, Taiwan
⨯
Yueh-Jan Wang,

Affiliation Department of Anatomy, College of Medicine, Tzu Chi University, Hualien, Taiwan
⨯
Min-Chuan Huang,

Affiliation Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
⨯
Guo-Fang Tseng

* E-mail: guofang@mail.tcu.edu.tw

Affiliation Department of Anatomy, College of Medicine, Tzu Chi University, Hualien, Taiwan
⨯

Methylcobalamin Facilitates Collateral Sprouting of Donor Axons and Innervation of Recipient Muscle in End-to-Side Neurorrhaphy in Rats

Wen-Chieh Liao,
Yueh-Jan Wang,
Min-Chuan Huang,
Guo-Fang Tseng

Published: September 30, 2013
https://doi.org/10.1371/journal.pone.0076302

About the Authors

Wen-Chieh Liao

Affiliation Department of Anatomy, Faculty of Medicine, Chung Shan Medical University and Department of Pediatrics, Chung Shan Medical University Hospital, Taichung City, Taiwan

Yueh-Jan Wang

Affiliation Department of Anatomy, College of Medicine, Tzu Chi University, Hualien, Taiwan

Min-Chuan Huang

Affiliation Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan

Guo-Fang Tseng

* E-mail: guofang@mail.tcu.edu.tw

Affiliation Department of Anatomy, College of Medicine, Tzu Chi University, Hualien, Taiwan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GFT. Performed the experiments: WCL. Analyzed the data: YJW MCH. Contributed reagents/materials/analysis tools: YJW MCH GFT. Wrote the manuscript: WCL YJW GFT.

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Axons
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Nerves
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Schwann cells
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Nerve regeneration
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Muscle electrophysiology
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Surgical repair
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Tissue repair
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Tubulins
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