About the Authors

Turki Abujamel

Affiliation Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ontario, Canada

Jennifer L. Cadnum

Affiliation Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, United States of America

Lucy A. Jury

Affiliation Geriatric Research, Education and Clinical Center, Cleveland, Ohio, United States of America

Venkata C. K. Sunkesula

Affiliation Department of Medicine, Infectious Diseases Division, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Sirisha Kundrapu

Affiliation Department of Medicine, Infectious Diseases Division, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Robin L. Jump

Affiliation Geriatric Research, Education and Clinical Center, Cleveland, Ohio, United States of America

Alain C. Stintzi

astintzi@uottawa.ca (AS); curtisd123@yahoo.com (CJD)

Affiliation Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ontario, Canada

Curtis J. Donskey

astintzi@uottawa.ca (AS); curtisd123@yahoo.com (CJD)

Affiliations Geriatric Research, Education and Clinical Center, Cleveland, Ohio, United States of America, Department of Medicine, Infectious Diseases Division, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Competing Interests

The authors received funding for the study from ViroPharma, Incorporated. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AS CJD. Performed the experiments: TA JLC LAJ VCKS SK. Analyzed the data: VCKS SK RLJ AS CJD. Wrote the manuscript: TA JLC AS CJD.