Sulfamethoxazole Induces a Switch Mechanism in T Cell Receptors Containing TCRVβ20-1, Altering pHLA Recognition

Stephan Watkins; Werner J. Pichler

doi:10.1371/journal.pone.0076211

Loading metrics

Open Access

Peer-reviewed

Research Article

Sulfamethoxazole Induces a Switch Mechanism in T Cell Receptors Containing TCRVβ20-1, Altering pHLA Recognition

Stephan Watkins ,

* E-mail: Stephan.lloyd@students.unibe.ch

Affiliations Department of Rheumatology, Clinical Immunology and Allergology, Inselspital/University Hospital of Bern, Bern, Switzerland, Department of Graduate Cell Biology, University of Bern, Bern, Switzerland
⨯
Werner J. Pichler

Affiliation Department of Rheumatology, Clinical Immunology and Allergology, Inselspital/University Hospital of Bern, Bern, Switzerland
⨯

Sulfamethoxazole Induces a Switch Mechanism in T Cell Receptors Containing TCRVβ20-1, Altering pHLA Recognition

Stephan Watkins,
Werner J. Pichler

Published: October 7, 2013
https://doi.org/10.1371/journal.pone.0076211

About the Authors

Stephan Watkins

* E-mail: Stephan.lloyd@students.unibe.ch

Affiliations Department of Rheumatology, Clinical Immunology and Allergology, Inselspital/University Hospital of Bern, Bern, Switzerland, Department of Graduate Cell Biology, University of Bern, Bern, Switzerland

Werner J. Pichler

Affiliation Department of Rheumatology, Clinical Immunology and Allergology, Inselspital/University Hospital of Bern, Bern, Switzerland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SW WJP. Performed the experiments: SW. Analyzed the data: SW. Contributed reagents/materials/analysis tools: WJP. Wrote the manuscript: SW WJP.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hydrogen bonding
Is the Subject Area "Hydrogen bonding" applicable to this article?

Thanks for your feedback.
Free energy
Is the Subject Area "Free energy" applicable to this article?

Thanks for your feedback.
Drug interactions
Is the Subject Area "Drug interactions" applicable to this article?

Thanks for your feedback.
T cell receptors
Is the Subject Area "T cell receptors" applicable to this article?

Thanks for your feedback.
Biochemical simulations
Is the Subject Area "Biochemical simulations" applicable to this article?

Thanks for your feedback.
Principal component analysis
Is the Subject Area "Principal component analysis" applicable to this article?

Thanks for your feedback.
Small molecules
Is the Subject Area "Small molecules" applicable to this article?

Thanks for your feedback.
TCR signaling cascade
Is the Subject Area "TCR signaling cascade" applicable to this article?

Thanks for your feedback.