About the Authors

Francesca Ferranti

Affiliation Department of Anatomy, Histology, Forensic Medicine and Orthopedics - Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy

Fabrizio D’Anselmi

Affiliations Department of Surgery “PietroValdoni”, Sapienza University of Rome, Rome, Italy, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

Maria Caruso

Affiliation Department of Anatomy, Histology, Forensic Medicine and Orthopedics - Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy

Vittorio Lei

Affiliation Farnia srl, Rome, Italy

Simona Dinicola

Affiliation Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy

Alessia Pasqualato

Affiliation Department of Neuroscience and Imaging, Section of Physiology and Physiopathology, “G. D’Annunzio” University of Chieti-Pescara, Chieti, Italy

Alessandra Cucina

Affiliation Department of Surgery “PietroValdoni”, Sapienza University of Rome, Rome, Italy

Alessandro Palombo

Affiliation Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

Giulia Ricci

giulia.ricci@unina2.it

Affiliation Department of Experimental Medicine, Second University of Naples, Naples, Italy

Angela Catizone

These authors also contributed equally to this work.

Affiliation Department of Anatomy, Histology, Forensic Medicine and Orthopedics - Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy

Mariano Bizzarri

These authors also contributed equally to this work.

Affiliation Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

Competing Interests

V. Lei is employed by Farnia srl. F. D'Anselmi, M. Bizzarri and Sapienza University of Rome have patented in Italy EW (patent # 0001400147) for its use in 2D and 3D cultures. Patent Title: "The use of morphogenetic field in cancer cell phenotype reversion". There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: FF FD A. Cucina GR A. Catizone MB. Performed the experiments: FF GR A. Catizone MC SD A. Pasqualato. Analyzed the data: FF VL A. Palombo GR. Contributed reagents/materials/analysis tools: A. Cucina A. Catizone GR FD. Wrote the manuscript: GR MB.