Natriuretic Peptide Receptor-C Agonist Attenuates the Expression of Cell Cycle Proteins and Proliferation of Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats: Role of Gi Proteins and MAPkinase/PI3kinase Signaling

Jasmine El Andalousi; Yuan Li; Madhu B. Anand-Srivastava

doi:10.1371/journal.pone.0076183

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Open Access

Peer-reviewed

Research Article

Natriuretic Peptide Receptor-C Agonist Attenuates the Expression of Cell Cycle Proteins and Proliferation of Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats: Role of Gi Proteins and MAPkinase/PI3kinase Signaling

Jasmine El Andalousi,

Affiliation Department of Physiology, Université de Montréal, Quebec, Canada
⨯
Yuan Li,

Affiliation Department of Physiology, Université de Montréal, Quebec, Canada
⨯
Madhu B. Anand-Srivastava

* E-mail: madhu.anand-srivastava@umontreal.ca

Affiliation Department of Physiology, Université de Montréal, Quebec, Canada
⨯

Natriuretic Peptide Receptor-C Agonist Attenuates the Expression of Cell Cycle Proteins and Proliferation of Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats: Role of Gi Proteins and MAPkinase/PI3kinase Signaling

Jasmine El Andalousi,
Yuan Li,
Madhu B. Anand-Srivastava

Published: October 14, 2013
https://doi.org/10.1371/journal.pone.0076183

About the Authors

Jasmine El Andalousi

Affiliation Department of Physiology, Université de Montréal, Quebec, Canada

Yuan Li

Affiliation Department of Physiology, Université de Montréal, Quebec, Canada

Madhu B. Anand-Srivastava

* E-mail: madhu.anand-srivastava@umontreal.ca

Affiliation Department of Physiology, Université de Montréal, Quebec, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MBA-S. Performed the experiments: JEA YL. Analyzed the data: JEA YL. Contributed reagents/materials/analysis tools: JEA YL. Wrote the paper: MBA-S.

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Cyclins
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Cell cycle and cell division
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Cell cycle inhibitors
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Protein expression
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Smooth muscle cells
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Pertussis
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Toxins
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DNA synthesis
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