About the Authors

Carla S. Verissimo

c.s.leiriaverissimo@umcutrecht.nl (CSV); e.vreugdenhil.HG@lumc.nl (EV)

Current address: Department of Molecular Cancer Research, Centre of Biomedical Genetics and Cancer Genomics Centre, University Medical Center Utrecht, Utrecht, The Netherlands

Affiliation Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, the Netherlands

Rachel Elands

Affiliation Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, the Netherlands

Sou Cheng

Affiliation Prosensa Therapeutics B.V., Leiden, the Netherlands

Dirk-Jan Saaltink

Affiliation Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, the Netherlands

Judith P. ter Horst

Affiliation Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, the Netherlands

Maria N. Alme

Affiliation Department of Biomedicine, K. G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway

Chantal Pont

Affiliation Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, the Netherlands

Bob van de Water

Affiliation Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, the Netherlands

Bjarte Håvik

Affiliations Dr. E. Martens Research Group for Biological Psychiatry, Department of Clinical Medicine, University of Bergen, Bergen, Norway, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway

Carlos P. Fitzsimons

Affiliation Centre for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands

Erno Vreugdenhil

c.s.leiriaverissimo@umcutrecht.nl (CSV); e.vreugdenhil.HG@lumc.nl (EV)

Affiliations Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, the Netherlands, Department of Human Genetics, Migraine Research Group, Leiden University Medical Center, Leiden, the Netherlands

Competing Interests

Sou Cheng is employed by Prosensa Therapeutics B.V. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: CSV RE MNA BH CPF EV. Performed the experiments: CSV RE SC DJS MNA CP. Analyzed the data: CSV RE JPH MNA BH. Contributed reagents/materials/analysis tools: BW BH. Wrote the manuscript: CSV BW BH CPF EV.