About the Authors

Ma’en Obeidat

Contributed equally to this work with: Ma’en Obeidat, Suzanne Miller

Affiliations Division of Respiratory Medicine, University of Nottingham, Queen’s Medical Center, Nottingham, United Kingdom, James Hogg Research Centre, Institute for Heart and Lung Health, University of British Columbia, Vancouver, British Columbia, Canada

Suzanne Miller

Contributed equally to this work with: Ma’en Obeidat, Suzanne Miller

Affiliation Division of Respiratory Medicine, University of Nottingham, Queen’s Medical Center, Nottingham, United Kingdom

Kelly Probert

Affiliation Division of Respiratory Medicine, University of Nottingham, Queen’s Medical Center, Nottingham, United Kingdom

Charlotte K. Billington

Affiliation Division of Respiratory Medicine, University of Nottingham, Queen’s Medical Center, Nottingham, United Kingdom

Amanda P. Henry

Affiliation Division of Respiratory Medicine, University of Nottingham, Queen’s Medical Center, Nottingham, United Kingdom

Emily Hodge

Affiliation Division of Respiratory Medicine, University of Nottingham, Queen’s Medical Center, Nottingham, United Kingdom

Carl P. Nelson

Affiliation Division of Respiratory Medicine, University of Nottingham, Queen’s Medical Center, Nottingham, United Kingdom

Ceri E. Stewart

Affiliation Division of Respiratory Medicine, University of Nottingham, Queen’s Medical Center, Nottingham, United Kingdom

Caroline Swan

Affiliation Division of Respiratory Medicine, University of Nottingham, Queen’s Medical Center, Nottingham, United Kingdom

Louise V. Wain

Affiliation Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, United Kingdom

María Soler Artigas

Affiliation Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, United Kingdom

Erik Melén

Affiliation Institute of Environmental Medicine, Karolinska Institutet and Sachs’ Children’s Hospital, Stockholm, Sweden

Kevin Ushey

Affiliation James Hogg Research Centre, Institute for Heart and Lung Health, University of British Columbia, Vancouver, British Columbia, Canada

Ke Hao

Affiliation Department of Genetics and Genomic Sciences, Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States of America

Maxime Lamontagne

Affiliation Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec City, Canada

Yohan Bossé

Affiliations Department of Molecular Medicine, Laval University, Québec City, Canada, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec City, Canada

Dirkje S. Postma

Affiliation Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Martin D. Tobin

Affiliations Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, United Kingdom, National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom

Ian Sayers

Affiliation Division of Respiratory Medicine, University of Nottingham, Queen’s Medical Center, Nottingham, United Kingdom

Ian P. Hall

ian.hall@nottingham.ac.uk

Affiliation Division of Respiratory Medicine, University of Nottingham, Queen’s Medical Center, Nottingham, United Kingdom

Competing Interests

The resequencing study performed at the University of Leicester was funded by Pfizer. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: MO SM KP CKB AH EH CPN CES CS LVW MSA EM KU KH ML YB DSP MDT IS IPH. Performed the experiments: MO SM KP CKB AH EH CPN CES CS LVW MSA EM KU KH ML YB DSP MDT IS IPH. Analyzed the data: MO SM KP CKB AH EH CPN CES CS LVW MSA EM KU KH ML YB DSP MDT IS IPH. Contributed reagents/materials/analysis tools: MO SM KP CKB AH EH CPN CES CS LVW EM KU KH ML YB DSP MDT IS IPH. Wrote the manuscript: MO CKB IPH. Approved the final version to be published: MO SM KP CKB AH EH CPN CES CS LVW MSA EM KU KH ML YB DSP MDT IS IPH. Revised the manuscript critically for important intellectual content: MO SM KP CKB AH EH CPN CES CS LVW MSA EM KU KH ML YB DSP MDT IS IPH. Made a substantial contribution to the conception or design of parts of the study: MO SM KP CKB AH EH CPN CES CS LVW MSA EM KU KH ML YB DSP MDT IS IPH. Made a significant contribution in data acquisition or the analysis and interpretation of data: MO SM KP CKB AH EH CPN CES CS LVW MSA EM KU KH ML YB DSP MDT IS IPH.