Allosteric Coupling between the Intracellular Coupling Helix 4 and Regulatory Sites of the First Nucleotide-binding Domain of CFTR

Jennifer E. Dawson; Patrick J. Farber; Julie D. Forman-Kay

doi:10.1371/journal.pone.0074347

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Open Access

Peer-reviewed

Research Article

Allosteric Coupling between the Intracellular Coupling Helix 4 and Regulatory Sites of the First Nucleotide-binding Domain of CFTR

Jennifer E. Dawson,

Affiliations Molecular Structure and Function Program, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
⨯
Patrick J. Farber,

Affiliations Molecular Structure and Function Program, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
⨯
Julie D. Forman-Kay

* E-mail: forman@sickkids.ca

Affiliations Molecular Structure and Function Program, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
⨯

Allosteric Coupling between the Intracellular Coupling Helix 4 and Regulatory Sites of the First Nucleotide-binding Domain of CFTR

Jennifer E. Dawson,
Patrick J. Farber,
Julie D. Forman-Kay

Published: September 18, 2013
https://doi.org/10.1371/journal.pone.0074347

About the Authors

Jennifer E. Dawson

Affiliations Molecular Structure and Function Program, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

Patrick J. Farber

Affiliations Molecular Structure and Function Program, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

Julie D. Forman-Kay

* E-mail: forman@sickkids.ca

Affiliations Molecular Structure and Function Program, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JED PJF. Performed the experiments: JED. Analyzed the data: JED PJF. Contributed reagents/materials/analysis tools: JED JFK. Wrote the paper: JED. Wrote the Matlab scripts used to analyze data: JED.

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Allosteric regulation
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Solubility
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Ion channel gating
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NMR spectroscopy
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Chemical elements
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Nucleotides
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Binding analysis
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Deletion mutation
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