About the Authors

Andreas Raue

Contributed equally to this work with: Andreas Raue, Marcel Schilling

andreas.raue@fdm.uni-freiburg.de

Affiliations Institute of Physics, University of Freiburg, Freiburg, Germany, Institute of Computational Biology, Helmholtz Center, Munich, Germany

Marcel Schilling

Contributed equally to this work with: Andreas Raue, Marcel Schilling

Affiliation Systems Biology of Signal Transduction, German Cancer Research Center-Center for Molecular Biology Alliance, Heidelberg, Germany

Julie Bachmann

Affiliation Systems Biology of Signal Transduction, German Cancer Research Center-Center for Molecular Biology Alliance, Heidelberg, Germany

Andrew Matteson

Affiliation Department of Computational Biology, New York University, New York, New York, United States of America

Max Schelke

Affiliation Institute of Physics, University of Freiburg, Freiburg, Germany

Daniel Kaschek

Affiliation Institute of Physics, University of Freiburg, Freiburg, Germany

Sabine Hug

Affiliations Institute of Computational Biology, Helmholtz Center, Munich, Germany, Center for Mathematical Sciences, Technical University Munich, Garching, Germany

Clemens Kreutz

Affiliation Institute of Physics, University of Freiburg, Freiburg, Germany

Brian D. Harms

Affiliation Merrimack Pharmaceuticals, Cambridge, Massachusetts, United States of America

Fabian J. Theis

Affiliations Institute of Computational Biology, Helmholtz Center, Munich, Germany, Center for Mathematical Sciences, Technical University Munich, Garching, Germany

Ursula Klingmüller

Affiliation Systems Biology of Signal Transduction, German Cancer Research Center-Center for Molecular Biology Alliance, Heidelberg, Germany

Jens Timmer

Affiliations Institute of Physics, University of Freiburg, Freiburg, Germany, Freiburg Institute for Advanced Studies, University of Freiburg, Freiburg, Germany, Zentrum für Biosystemanalyse, University of Freiburg, Freiburg, Germany, BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany

Competing Interests

BH works for a commercial company (Merrimack Pharmaceuticals). This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AR Marcel Shilling BH FJT UK JT. Performed the experiments: AR Marcel Shilling JB AM Max Schelker DK SH CK. Analyzed the data: AR Marcel Shilling AM. Wrote the paper: AR Marcel Shilling JB AM Max Schelker DK SH CK BH FJT UK JT.