About the Authors

Chao-Sheng Cheng

Affiliation Institute of Bioinformatics and Structural Biology and College of Life Sciences, National Tsing Hua University, Hsinchu, Taiwan

Kai-Fan Jia

Affiliation Institute of Bioinformatics and Structural Biology and College of Life Sciences, National Tsing Hua University, Hsinchu, Taiwan

Ting Chen

Affiliation Institute of Bioinformatics and Structural Biology and College of Life Sciences, National Tsing Hua University, Hsinchu, Taiwan

Shun-Ya Chang

Affiliation Institute of Bioinformatics and Structural Biology and College of Life Sciences, National Tsing Hua University, Hsinchu, Taiwan

Ming-Shen Lin

Affiliation TA Instruments-Waters LLC, Taipei, Taiwan

Hsien-Sheng Yin

hstin@mx.nthu.edu.tw

Affiliation Institute of Bioinformatics and Structural Biology and College of Life Sciences, National Tsing Hua University, Hsinchu, Taiwan

Competing Interests

The authors have the following interests: Co-author Ming-Shen Lin is employed by TA Instruments-Waters LLC. There are no patents, products in development or marketed products to declare. This does not alter their adherence to all the PLOS ONE policies on sharing data and materials, as detailed online on the guide for authors.

Author Contributions

Conceived and designed the experiments: HSY. Performed the experiments: CSC KFJ SYC MSL. Analyzed the data: CSC KFJ. Contributed reagents/materials/analysis tools: CSC KFJ SYC MSL HSY TC. Wrote the manuscript: HSY CSC TC. N/A.