Major Differences between Tumor and Normal Human Cell Fates after Exposure to Chemotherapeutic Monofunctional Alkylator

Maithili Gupte; Andrew N. Tuck; Vishal P. Sharma; Kandace J. Williams

doi:10.1371/journal.pone.0074071

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Open Access

Peer-reviewed

Research Article

Major Differences between Tumor and Normal Human Cell Fates after Exposure to Chemotherapeutic Monofunctional Alkylator

Maithili Gupte,

Affiliation Amgen, Seattle, Washington, United States of America
⨯
Andrew N. Tuck,

Affiliation Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Vishal P. Sharma,

Affiliation Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio, United States of America
⨯
Kandace J. Williams

* E-mail: Kandace.williams@utoledo.edu

Affiliation Department of Biochemistry and Cancer Biology, University of Toledo College of Medicine, Toledo, Ohio, United States of America
⨯

Major Differences between Tumor and Normal Human Cell Fates after Exposure to Chemotherapeutic Monofunctional Alkylator

Maithili Gupte,
Andrew N. Tuck,
Vishal P. Sharma,
Kandace J. Williams

Published: September 3, 2013
https://doi.org/10.1371/journal.pone.0074071

About the Authors

Maithili Gupte

Affiliation Amgen, Seattle, Washington, United States of America

Andrew N. Tuck

Affiliation Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

Vishal P. Sharma

Affiliation Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio, United States of America

Kandace J. Williams

* E-mail: Kandace.williams@utoledo.edu

Affiliation Department of Biochemistry and Cancer Biology, University of Toledo College of Medicine, Toledo, Ohio, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KJW. Performed the experiments: MG ANT VPS. Analyzed the data: KJW MG ANT VPS. Contributed reagents/materials/analysis tools: KJW. Wrote the manuscript: KJW.

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Cancer treatment
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Apoptosis
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Cell cycle and cell division
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Cell metabolism
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Cancers and neoplasms
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Cell death
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Addition reactions
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DNA damage
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