Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress

Yusuke S. Hori; Atsushi Kuno; Ryusuke Hosoda; Yoshiyuki Horio

doi:10.1371/journal.pone.0073875

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Open Access

Peer-reviewed

Research Article

Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress

Yusuke S. Hori ,

Contributed equally to this work with: Yusuke S. Hori, Atsushi Kuno, Ryusuke Hosoda

Affiliation Department of Pharmacology, School of Medicine, Sapporo Medical University, Sapporo, Japan
⨯
Atsushi Kuno ,

Contributed equally to this work with: Yusuke S. Hori, Atsushi Kuno, Ryusuke Hosoda

Affiliations Department of Pharmacology, School of Medicine, Sapporo Medical University, Sapporo, Japan, Department of Cardiovascular, Renal, and Metabolic Medicine, School of Medicine, Sapporo Medical University, Sapporo, Japan
⨯
Ryusuke Hosoda ,

Contributed equally to this work with: Yusuke S. Hori, Atsushi Kuno, Ryusuke Hosoda

Affiliation Department of Pharmacology, School of Medicine, Sapporo Medical University, Sapporo, Japan
⨯
Yoshiyuki Horio

* E-mail: horio@sapmed.ac.jp

Affiliation Department of Pharmacology, School of Medicine, Sapporo Medical University, Sapporo, Japan
⨯

Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress

Yusuke S. Hori,
Atsushi Kuno,
Ryusuke Hosoda,
Yoshiyuki Horio

Published: September 11, 2013
https://doi.org/10.1371/journal.pone.0073875

About the Authors

Yusuke S. Hori

Contributed equally to this work with: Yusuke S. Hori, Atsushi Kuno, Ryusuke Hosoda

Affiliation Department of Pharmacology, School of Medicine, Sapporo Medical University, Sapporo, Japan

Atsushi Kuno

Contributed equally to this work with: Yusuke S. Hori, Atsushi Kuno, Ryusuke Hosoda

Affiliations Department of Pharmacology, School of Medicine, Sapporo Medical University, Sapporo, Japan, Department of Cardiovascular, Renal, and Metabolic Medicine, School of Medicine, Sapporo Medical University, Sapporo, Japan

Ryusuke Hosoda

Contributed equally to this work with: Yusuke S. Hori, Atsushi Kuno, Ryusuke Hosoda

Affiliation Department of Pharmacology, School of Medicine, Sapporo Medical University, Sapporo, Japan

Yoshiyuki Horio

* E-mail: horio@sapmed.ac.jp

Affiliation Department of Pharmacology, School of Medicine, Sapporo Medical University, Sapporo, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YSH AK YH. Performed the experiments: YSH RH. Analyzed the data: YSH AK YH. Wrote the paper: YSH AK YH.

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Apoptosis
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Transfection
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Oxidative stress
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Small interfering RNA
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Transcription factors
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Immunostaining
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Reactive oxygen species
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Acetylation
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