About the Authors

Ting-Yu Lai

Affiliation Institute of Molecular Medicine, National Taiwan University, Taipei, Taiwan

Shang-Duen Wu

Affiliation Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan

Mong-Hsun Tsai

Affiliations Institute of Biotechnology, National Taiwan University, Taipei, Taiwan, Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan

Eric Y. Chuang

Affiliations Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan, YongLin Biomedical Engineering Center, National Taiwan University, Taipei, Taiwan

Li-Ling Chuang

Affiliation Department of Physical Therapy and Graduate Institute of Rehabilitation Science, Chang Gung University, Taoyuan, Taiwan

Li-Chung Hsu

lichunghsu@ntu.edu.tw (L-CH); llai@ntu.edu.tw (L-CL)

Affiliation Institute of Molecular Medicine, National Taiwan University, Taipei, Taiwan

Liang-Chuan Lai

lichunghsu@ntu.edu.tw (L-CH); llai@ntu.edu.tw (L-CL)

Affiliations Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan, Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan

Competing Interests

The co-author Eric Y. Chuang is a PLOS ONE Editorial Board member. However, this does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LCH LCL. Performed the experiments: TYL SDW. Analyzed the data: SDW MHT EYC LLC LCL. Contributed reagents/materials/analysis tools: MHT EYC. Wrote the paper: TYL SDW LCH LCL.