About the Authors

Christian W. Grant

Affiliation Biomedical Research Models (BRM), Inc., Worcester and Springfield, Massachusetts, United States of America

Catherine M. Moran-Paul

Affiliation Biomedical Research Models (BRM), Inc., Worcester and Springfield, Massachusetts, United States of America

Shane K. Duclos

Affiliation Biomedical Research Models (BRM), Inc., Worcester and Springfield, Massachusetts, United States of America

Dennis L. Guberski

Affiliation Biomedical Research Models (BRM), Inc., Worcester and Springfield, Massachusetts, United States of America

Guillermo Arreaza-Rubín

Affiliation National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland, United States of America

Lisa M. Spain

spainL@niddk.nih.gov

Affiliation National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland, United States of America

Competing Interests

Dennis Guberski has a financial interest (direct equity ownership, >25% of the common stock of BRM, Inc.) in the development and commercialization of animal models of human disease. DLG, CWG, CMMP, and SKD are or were employed by Biomedical Research Models, Inc., a company that develops and provides animal models of human disease. There are no patents, products in development or marketed products to declare. BRM does not have any financial interest in any of the agents that have been tested under the T1D-PTP project. BRM is an independent contract research organization that offers preclinical services. Therefore, no financial or nonfinancial conflicts of interest are present with respect to this manuscript or any of the organizations that provided agents for testing. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors. Guillermo Arreaza-Rubin and Lisa M. Spain have no potentially competing financial interests to declare.

Author Contributions

Conceived and designed the experiments: CWG CMMP SKD DLG GAR LMS. Performed the experiments: CWG CMMP SKD. Analyzed the data: CWG CMMP SKD DLG GAR LMS. Wrote the manuscript: CWG DLG GAR LMS. Signed Materials Tranfer Agreements for the use of donated materials: GAR.