About the Authors

Anastasia Wyce

Affiliation Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Gopinath Ganji

Affiliation Molecular Medicine Unit, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Kimberly N. Smitheman

Affiliation Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Chun-wa Chung

Affiliation Platform Technology and Science, GlaxoSmithKline, Stevenage, United Kingdom

Susan Korenchuk

Affiliation Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Yuchen Bai

Affiliation Molecular Medicine Unit, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Olena Barbash

Affiliation Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

BaoChau Le

Affiliation Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Peter D. Craggs

Affiliation Platform Technology and Science, GlaxoSmithKline, Stevenage, United Kingdom

Michael T. McCabe

Affiliation Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Karen M. Kennedy-Wilson

Affiliation Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Lydia V. Sanchez

Affiliation Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Romain L. Gosmini

Affiliation Lipid Metabolism Discovery Performance Unit, GlaxoSmithKline, Les Ulis, France

Nigel Parr

Affiliation Epinova Discovery Performance Unit, GlaxoSmithKline, Stevenage, United Kingdom

Charles F. McHugh

Affiliation Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Dashyant Dhanak

Affiliation Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Rab K. Prinjha

Affiliation Epinova Discovery Performance Unit, GlaxoSmithKline, Stevenage, United Kingdom

Kurt R. Auger

Affiliation Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Peter J. Tummino

Peter.J.Tummino@gsk.com

Affiliation Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Competing Interests

The authors have read the journal's competing interest policy and have the following conflicts to disclose: all authors are current or former employees of GlaxoSmithKline. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AW PC KS CC SK RP DD KA PT. Performed the experiments: AW SK KS BL CC PC RG YB MTM. Analyzed the data: AW GG KS CC SK BL CM YB MTM. Contributed reagents/materials/analysis tools: KKW LS RG NP. Wrote the manuscript: AW OB KA PT.