About the Authors

Xunlong Shi

Contributed equally to this work with: Xunlong Shi, Jianjun Yang

Affiliation Department of Biosynthesis, School of Pharmacy, Fudan University, Shanghai, China

Jianjun Yang

Contributed equally to this work with: Xunlong Shi, Jianjun Yang

Affiliation Shanghai Meiye Biotech Institute, Shanghai, China

Haiyan Zhu

Affiliation Department of Biosynthesis, School of Pharmacy, Fudan University, Shanghai, China

Li Ye

Affiliation Department of Biosynthesis, School of Pharmacy, Fudan University, Shanghai, China

Meiqing Feng

Affiliation Department of Biosynthesis, School of Pharmacy, Fudan University, Shanghai, China

Jiyang Li

Affiliation Department of Biosynthesis, School of Pharmacy, Fudan University, Shanghai, China

Hai Huang

Affiliation Department of Biosynthesis, School of Pharmacy, Fudan University, Shanghai, China

Qun Tao

Affiliation Shanghai Meiye Biotech Institute, Shanghai, China

Dan Ye

Affiliation Shanghai Meiye Biotech Institute, Shanghai, China

Lee-Hwei K. Sun

Affiliation PharMab (Shanghai), Inc., Shanghai, China

Bill N. C. Sun

Affiliation PharMab (Shanghai), Inc., Shanghai, China

Cecily R. Y. Sun

Affiliation PharMab (Shanghai), Inc., Shanghai, China

Guizhen Han

Affiliation Department of Pharmacology, School of Medicine, Fudan University, Shanghai, China

Yuanyuan Liu

Affiliation Department of Pharmacology, School of Medicine, Fudan University, Shanghai, China

Minghui Yao

Affiliation Department of Pharmacology, School of Medicine, Fudan University, Shanghai, China

Pei Zhou

Affiliation Department of Biosynthesis, School of Pharmacy, Fudan University, Shanghai, China

Dianwen Ju

dianwenju@fudan.edu.cn

Affiliation Department of Biosynthesis, School of Pharmacy, Fudan University, Shanghai, China

Competing Interests

QT, DY, DJ are founders and JY is an employee of Meiyer Biotech Institute, and LHKS, BNCS, CRYS are founders of PharMab, Inc. This affiliation, however, does not in anyway alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. The other authors report no conflict of interest.

Author Contributions

Conceived and designed the experiments: QT DY BNCS MY DJ. Performed the experiments: XS JY HZ JL HH LY MF GH YL. Analyzed the data: LHKS CRYS YL MY PZ. Wrote the paper: XS PZ DJ.