About the Authors

Yuuichi Soeno

soeno-path@tky.ndu.ac.jp

Affiliation Department of Pathology, School of Life Dentistry, The Nippon Dental University, Tokyo, Japan

Kazuya Fujita

Affiliation Department of Pathology, School of Life Dentistry, The Nippon Dental University, Tokyo, Japan

Tomoo Kudo

Affiliation Department of Pathology, Hyogo College of Medicine, Hyogo, Japan

Masataka Asagiri

Affiliation Innovation Center for Immunoregulation and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Shigeru Kakuta

Affiliations Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Yuji Taya

Affiliation Department of Pathology, School of Life Dentistry, The Nippon Dental University, Tokyo, Japan

Yoshihito Shimazu

Affiliation Department of Pathology, School of Life Dentistry, The Nippon Dental University, Tokyo, Japan

Kaori Sato

Affiliation Department of Pathology, School of Life Dentistry, The Nippon Dental University, Tokyo, Japan

Ritsuko Tanaka-Fujita

Affiliation Risk Assessment Division, Food Safety Commission Secretariat, Cabinet Office, Government of Japan, Tokyo, Japan

Sachiko Kubo

Affiliations Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan, Division of Experimental Animal Immunology, Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan

Yoichiro Iwakura

Affiliations Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan, Division of Experimental Animal Immunology, Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan

Yoshikazu Nakamura

Affiliations Division of RNA Medical Science, Institute of Medical Science, University of Tokyo, Tokyo, Japan, Ribomic Inc., Tokyo, Japan

Shigeo Mori

Affiliation Kotobiken Medical Laboratories Inc., Tokyo, Japan

Takaaki Aoba

Affiliation Department of Pathology, School of Life Dentistry, The Nippon Dental University, Tokyo, Japan

Competing Interests

Authors Yoshikazu Nakamura and Shigeo Mori are employed by Ribomic Inc. and Kotobiken Medical Laboratories Inc., respectively. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: Y. Soeno MA S. Kakuta RTF SM TA. Performed the experiments: Y. Soeno KF TK YT Y. Shimazu KS S. Kubo. Analyzed the data: Y. Soeno MA S. Kakuta KS TA. Contributed reagents/materials/analysis tools: S. Kubo YI YN SM. Wrote the paper: Y. Soeno TA.