About the Authors

Yin-Hsiu Chien

Contributed equally to this work with: Yin-Hsiu Chien, Der-Sheng Han

Affiliation Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan

Der-Sheng Han

Contributed equally to this work with: Yin-Hsiu Chien, Der-Sheng Han

Affiliations Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan, Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, BeiHu Branch, Taipei, Taiwan, Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan

Wuh-Liang Hwu

Affiliation Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan

Beth L. Thurberg

Affiliation Department of Pathology, Genzyme, a Sanofi company, Framingham, Massachusetts, United States of America

Wei-Shiung Yang

wsyang@ntu.edu.tw

Affiliations Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan

Competing Interests

Beth L. Thurberg is an employee of Genzyme (a Sanofi company). There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YHC DSH WLH WSY. Performed the experiments: YHC DSH BLT. Analyzed the data: YHC DSH BLT. Contributed reagents/materials/analysis tools: YHC DSH BLT WSY. Wrote the paper: YHC DSH WLH BLT WSY.