About the Authors

Yui Shikiya

Affiliation Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan

Shunsuke Tomita

Affiliation Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, Japan

Tsutomu Arakawa

Affiliation Alliance Protein Laboratories, San Diego, California, United States of America

Kentaro Shiraki

shiraki@bk.tsukuba.ac.jp

Affiliation Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan

Competing Interests

The authors have the following interests: Co-author Tsutomu Arakawa is employed by Alliance Protein Laboratories. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YS ST TA KS. Performed the experiments: YS. Analyzed the data: YS. Contributed reagents/materials/analysis tools: YS ST TA KS. Wrote the paper: YS ST TA KS.