An Inhibitor of the δPKC Interaction with the d Subunit of F1Fo ATP Synthase Reduces Cardiac Troponin I Release from Ischemic Rat Hearts: Utility of a Novel Ammonium Sulfate Precipitation Technique

Mourad Ogbi; Ijeoma Obi; John A. Johnson

doi:10.1371/journal.pone.0070580

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Peer-reviewed

Research Article

An Inhibitor of the δPKC Interaction with the d Subunit of F₁Fo ATP Synthase Reduces Cardiac Troponin I Release from Ischemic Rat Hearts: Utility of a Novel Ammonium Sulfate Precipitation Technique

Mourad Ogbi,

Affiliation Department of Pharmacology & Toxicology and Program in Regenerative Medicine, Institute of Molecular Medicine and Genetics, Georgia Regents University, Augusta, Georgia, United States of America
⨯
Ijeoma Obi,

Affiliation Department of Pharmacology & Toxicology and Program in Regenerative Medicine, Institute of Molecular Medicine and Genetics, Georgia Regents University, Augusta, Georgia, United States of America
⨯
John A. Johnson

* E-mail: jjohnson@gru.edu

Affiliation Department of Pharmacology & Toxicology and Program in Regenerative Medicine, Institute of Molecular Medicine and Genetics, Georgia Regents University, Augusta, Georgia, United States of America
⨯

An Inhibitor of the δPKC Interaction with the d Subunit of F₁Fo ATP Synthase Reduces Cardiac Troponin I Release from Ischemic Rat Hearts: Utility of a Novel Ammonium Sulfate Precipitation Technique

Mourad Ogbi,
Ijeoma Obi,
John A. Johnson

Published: August 1, 2013
https://doi.org/10.1371/journal.pone.0070580

About the Authors

Mourad Ogbi

Affiliation Department of Pharmacology & Toxicology and Program in Regenerative Medicine, Institute of Molecular Medicine and Genetics, Georgia Regents University, Augusta, Georgia, United States of America

Ijeoma Obi

John A. Johnson

* E-mail: jjohnson@gru.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MO JAJ IO. Performed the experiments: MO JAJ IO. Analyzed the data: MO JAJ IO. Contributed reagents/materials/analysis tools: JAJ. Wrote the paper: MO JAJ IO.

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Heart
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Mitochondria
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Reperfusion
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Chemical precipitation
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Immune serum
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Ischemia
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Cardiac ventricles
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Troponin
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