About the Authors

Katrina L. Paumier

Affiliation Neuroscience Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America

Stacey J. Sukoff Rizzo

Affiliation Neuroscience Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America

Zdenek Berger

Affiliation Neuroscience Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America

Yi Chen

Affiliation Neuroscience Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America

Cathleen Gonzales

Affiliation Neuroscience Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America

Edward Kaftan

Current address: Department of Pharmacology, Yale University, New Haven, Connecticut, United States of America

Affiliation Neuroscience Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America

Li Li

Affiliation Neuroscience Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America

Susan Lotarski

Affiliation Neuroscience Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America

Michael Monaghan

Affiliation Neuroscience Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America

Wei Shen

Affiliation Neuroscience Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America

Polina Stolyar

Affiliation Neuroscience Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America

Dmytro Vasilyev

Current address: Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University, New Haven, Connecticut, United States of America

Affiliation Neuroscience Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America

Margaret Zaleska

Affiliation Neuroscience Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America

Warren D. Hirst

warren.hirst@pfizer.com

Affiliation Neuroscience Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America

John Dunlop

Current address: AstraZeneca, Department of Neuroscience, Cambridge, Massachusetts, United States of America

Affiliation Neuroscience Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have the following conflicts: All authors were employed by Pfizer when the studies were conducted. This project was funded in part by Pfizer. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KP MM WH JD MZ. Performed the experiments: KP SSR CG YC EK SL PS DV. Analyzed the data: KP SSR ZB YC CG EK LL SL WS PS DV MZ WH JD. Contributed reagents/materials/analysis tools: MZ WH JD. Wrote the paper: KP EK SR.