About the Authors

Jiwang Chen

chenjw@uic.edu

Affiliations Department of Medicine, Northwestern University, Chicago, Illinois, United States of America, Section of Pulmonary, Critical Care Medicine, Allergy and Sleep, University of Illinois at Chicago, Chicago, Illinois, United States of America

Gang Feng

Affiliation Northwestern University Biomedical Informatics Center, Chicago, Illinois, United States of America

Qiang Guo

Affiliation Section of Pulmonary, Critical Care Medicine, Allergy and Sleep, University of Illinois at Chicago, Chicago, Illinois, United States of America

Juliane B. Wardenburg

Affiliation Department of Pediatrics, University of Chicago, Chicago, Illinois, United States of America

Simon Lin

Affiliations Northwestern University Biomedical Informatics Center, Chicago, Illinois, United States of America, Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States of America

Ichiro Inoshima

Affiliation Department of Pediatrics, University of Chicago, Chicago, Illinois, United States of America

Ryan Deaton

Affiliation Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, United States of America

Jason X. J. Yuan

Affiliation Section of Pulmonary, Critical Care Medicine, Allergy and Sleep, University of Illinois at Chicago, Chicago, Illinois, United States of America

Joe G. N. Garcia

Affiliation Section of Pulmonary, Critical Care Medicine, Allergy and Sleep, University of Illinois at Chicago, Chicago, Illinois, United States of America

Roberto F. Machado

Affiliation Section of Pulmonary, Critical Care Medicine, Allergy and Sleep, University of Illinois at Chicago, Chicago, Illinois, United States of America

Michael Otto

Affiliation National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America

Richard G. Wunderink

Affiliation Department of Medicine, Northwestern University, Chicago, Illinois, United States of America

Competing Interests

This project was supported by Pfizer Inc. The authors state that this does not alter their adherence to all the PLOS ONE policies on sharing data and materials. All the coauthors, except Dr. Richard Wunderink, have declared that there is not any potential competing interest. Dr. Richard Wunderink supplied the following declaration: "Dr. Wunderink has received an investigator-initiated grant, participated in a clinical trial, and is a member of a data safety monitoring board with unrelated compounds/diagnostic tests for Pfizer".

Author Contributions

Conceived and designed the experiments: JC RW SL MO JBW JY JG RM. Performed the experiments: JC QG. Analyzed the data: JC GF SL RD. Contributed reagents/materials/analysis tools: JBW II MO. Wrote the paper: JC MO GF RW.