Mechanisms of Nrf2 Protection in Astrocytes as Identified by Quantitative Proteomics and siRNA Screening

James A. Dowell; Jeffrey A. Johnson

doi:10.1371/journal.pone.0070163

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Open Access

Peer-reviewed

Research Article

Mechanisms of Nrf2 Protection in Astrocytes as Identified by Quantitative Proteomics and siRNA Screening

James A. Dowell,

Affiliation Division of Pharmaceutical Science, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
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Jeffrey A. Johnson

* E-mail: jajohnson@pharmacy.wisc.edu

Affiliations Division of Pharmaceutical Science, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Molecular and Environmental Toxicology Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Center of Neuroscience, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯

Mechanisms of Nrf2 Protection in Astrocytes as Identified by Quantitative Proteomics and siRNA Screening

James A. Dowell,
Jeffrey A. Johnson

Published: July 29, 2013
https://doi.org/10.1371/journal.pone.0070163

About the Authors

James A. Dowell

Affiliation Division of Pharmaceutical Science, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

Jeffrey A. Johnson

* E-mail: jajohnson@pharmacy.wisc.edu

Affiliations Division of Pharmaceutical Science, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Molecular and Environmental Toxicology Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Center of Neuroscience, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JAD JAJ. Performed the experiments: JAD. Analyzed the data: JAD. Contributed reagents/materials/analysis tools: JAD JAJ. Wrote the paper: JAD.

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Astrocytes
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Small interfering RNA
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Glutathione
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Stable isotope labeling by amino acids in cell culture
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Oxidative stress
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Oxidation
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