The Biological Clock is Regulated by Adrenergic Signaling in Brown Fat but is Dispensable for Cold-Induced Thermogenesis

Siming Li; Qi Yu; Guo-Xiao Wang; Jiandie D. Lin

doi:10.1371/journal.pone.0070109

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Open Access

Peer-reviewed

Research Article

The Biological Clock is Regulated by Adrenergic Signaling in Brown Fat but is Dispensable for Cold-Induced Thermogenesis

Siming Li,

Affiliation Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Qi Yu,

Affiliation Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Guo-Xiao Wang,

Affiliation Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Jiandie D. Lin

* E-mail: jdlin@umich.edu

Affiliation Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
⨯

The Biological Clock is Regulated by Adrenergic Signaling in Brown Fat but is Dispensable for Cold-Induced Thermogenesis

Siming Li,
Qi Yu,
Guo-Xiao Wang,
Jiandie D. Lin

Published: August 26, 2013
https://doi.org/10.1371/journal.pone.0070109

About the Authors

Siming Li

Affiliation Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

Qi Yu

Affiliation Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

Guo-Xiao Wang

Affiliation Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

Jiandie D. Lin

* E-mail: jdlin@umich.edu

Affiliation Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SL JDL. Performed the experiments: SL QY GXW. Analyzed the data: SL JDL. Wrote the paper: SL JDL.

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Gene expression
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Adipose tissue
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Adipocytes
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Brown adipose tissue
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Body temperature
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Adipocyte differentiation
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Thermogenesis
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Gene regulation
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