About the Authors

Denise Harhausen

denise.harhausen@charite.de

Affiliations Department of Experimental Neurology, Charité – Universitätsmedizin Berlin, Berlin, Germany, Center for Stroke Research Berlin (CSB), Berlin, Germany

Violetta Sudmann

Affiliation Global Drug Discovery, Bayer Healthcare, Berlin, Germany

Uldus Khojasteh

Affiliation Department of Experimental Neurology, Charité – Universitätsmedizin Berlin, Berlin, Germany

Jochen Müller

Affiliation Department of Experimental Neurology, Charité – Universitätsmedizin Berlin, Berlin, Germany

Marietta Zille

Affiliations Department of Experimental Neurology, Charité – Universitätsmedizin Berlin, Berlin, Germany, Center for Stroke Research Berlin (CSB), Berlin, Germany

Keith Graham

Affiliation Global Drug Discovery, Bayer Healthcare, Berlin, Germany

Andrea Thiele

Affiliation Global Drug Discovery, Bayer Healthcare, Berlin, Germany

Thomas Dyrks

Affiliation Global Drug Discovery, Bayer Healthcare, Berlin, Germany

Ulrich Dirnagl

Affiliations Department of Experimental Neurology, Charité – Universitätsmedizin Berlin, Berlin, Germany, Center for Stroke Research Berlin (CSB), Berlin, Germany

Andreas Wunder

Affiliations Department of Experimental Neurology, Charité – Universitätsmedizin Berlin, Berlin, Germany, Center for Stroke Research Berlin (CSB), Berlin, Germany

Competing Interests

Thomas Dyrks, Andrea Thiele, Keith Graham, Violetta Sudmann are employees of Bayer Pharma AG, Berlin, Germany and they hereby declare that they participated in the preclinical preparation for this study as well as the manuscript preparation. They have seen and approved the final version. None of the products in the manuscript are under development or seeking patent approval. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DH AT TD UD AW. Performed the experiments: DH VS UK JM MZ KG AW. Analyzed the data: DH UK MZ AT AW. Contributed reagents/materials/analysis tools: AT TD AW UD. Wrote the paper: DH MZ AT UD AW.