Nucleic Acid Scavenging Polymers Inhibit Extracellular DNA-Mediated Innate Immune Activation without Inhibiting Anti-Viral Responses

Eda K. Holl; Kara L. Shumansky; George Pitoc; Elizabeth Ramsburg; Bruce A. Sullenger

doi:10.1371/journal.pone.0069413

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Peer-reviewed

Research Article

Nucleic Acid Scavenging Polymers Inhibit Extracellular DNA-Mediated Innate Immune Activation without Inhibiting Anti-Viral Responses

Eda K. Holl,

Affiliations Department of Surgery, Duke University, Durham, North Carolina, United States of America, Duke Translational Research Institute, Duke University, Durham, North Carolina, United States of America
⨯
Kara L. Shumansky,

Affiliations Department of Surgery, Duke University, Durham, North Carolina, United States of America, Duke Translational Research Institute, Duke University, Durham, North Carolina, United States of America
⨯
George Pitoc,

Affiliations Department of Surgery, Duke University, Durham, North Carolina, United States of America, Duke Translational Research Institute, Duke University, Durham, North Carolina, United States of America
⨯
Elizabeth Ramsburg,

Affiliation Department of Medicine, Duke University, Durham, North Carolina, United States of America
⨯
Bruce A. Sullenger

* E-mail: bruce.sullenger@duke.edu

Affiliations Department of Surgery, Duke University, Durham, North Carolina, United States of America, Duke Translational Research Institute, Duke University, Durham, North Carolina, United States of America
⨯

Nucleic Acid Scavenging Polymers Inhibit Extracellular DNA-Mediated Innate Immune Activation without Inhibiting Anti-Viral Responses

Eda K. Holl,
Kara L. Shumansky,
George Pitoc,
Elizabeth Ramsburg,
Bruce A. Sullenger

Published: July 23, 2013
https://doi.org/10.1371/journal.pone.0069413

About the Authors

Eda K. Holl

Affiliations Department of Surgery, Duke University, Durham, North Carolina, United States of America, Duke Translational Research Institute, Duke University, Durham, North Carolina, United States of America

Kara L. Shumansky

George Pitoc

Elizabeth Ramsburg

Affiliation Department of Medicine, Duke University, Durham, North Carolina, United States of America

Bruce A. Sullenger

* E-mail: bruce.sullenger@duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EKH ER BAS. Performed the experiments: EKH KLS. Analyzed the data: EKH KLS. Contributed reagents/materials/analysis tools: EKH KLS GP ER BAS. Wrote the paper: EKH BAS.

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T cells
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Polymers
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B cells
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Toll-like receptors
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Nucleic acids
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Cytokines
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Flow cytometry
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Immune response
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