About the Authors

Takahiro Suzuki

Contributed equally to this work with: Takahiro Suzuki, Masami Shimoda

Affiliations National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan, Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan

Masami Shimoda

Contributed equally to this work with: Takahiro Suzuki, Masami Shimoda

Affiliation National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan

Kumpei Ito

Affiliations National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan, Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan

Shuji Hanai

Affiliation National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan

Hidenobu Aizawa

Affiliation National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan

Tomoki Kato

Affiliation National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan

Kazunori Kawasaki

Affiliation National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan

Terumi Yamaguchi

Affiliation National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan

Hyung Don Ryoo

Affiliation Department of Cell Biology, New York University School of Medicine, New York, New York, United States of America

Naoko Goto-Inoue

Affiliation Graduate School of Health Promotion Sciences, Tokyo Metropolitan University, Tokyo, Japan

Mitsutoshi Setou

Affiliation Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, Shizuoka, Japan

Shoji Tsuji

Affiliation Department of Neurology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan

Norio Ishida

n.ishida@aist.go.jp

Affiliations National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan, Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan

Competing Interests

This work was funded in part by a grant from Nihon Advanced Agri Corporation. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TS M. Shimoda NI. Performed the experiments: TS TK. Analyzed the data: TS. Contributed reagents/materials/analysis tools: M. Shimoda HDR ST NI. Wrote the paper: TS M. Shimoda. Guided the experiments: KI SH HA KK TY NG M. Setou ST. Provided substantial input into the writing of the manuscript: ST NI.