About the Authors
- Georg Mohr
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Contributed equally to this work with: Georg Mohr, Wei Hong
Affiliation Section of Molecular Genetics and Microbiology, Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, School of Biological Sciences, University of Texas at Austin, Austin, Texas, United States of America
- Wei Hong
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Contributed equally to this work with: Georg Mohr, Wei Hong
Affiliations Shandong Provincial Key Laboratory of Energy Genetics, and Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, People’s Republic of China, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, People’s Republic of China
- Jie Zhang
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Affiliations Shandong Provincial Key Laboratory of Energy Genetics, and Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, People’s Republic of China, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, People’s Republic of China
- Gu-zhen Cui
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Affiliation Shandong Provincial Key Laboratory of Energy Genetics, and Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, People’s Republic of China
- Yunfeng Yang
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Affiliation State Key Joint Laboratory of Environment, Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing, People’s Republic of China
- Qiu Cui
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Affiliation Shandong Provincial Key Laboratory of Energy Genetics, and Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, People’s Republic of China
- Ya-jun Liu
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* E-mail: lambowitz@austin.utexas.edu (AL); liuyj@qibebt.ac.cn (YL)
Affiliation Shandong Provincial Key Laboratory of Energy Genetics, and Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, People’s Republic of China
- Alan M. Lambowitz
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* E-mail: lambowitz@austin.utexas.edu (AL); liuyj@qibebt.ac.cn (YL)
Affiliation Section of Molecular Genetics and Microbiology, Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, School of Biological Sciences, University of Texas at Austin, Austin, Texas, United States of America
Competing Interests
Targetron technology is subject to the following issued patents and patent applications: US 5,698,421, Ribonucleoprotein particles for cleaving double-stranded DNA and inserting an RNA/DNA molecule into the cleavage site; US 5,804,418, Methods for preparing nucleotide integrases; US 5,869,634, Method of making an RNP particle for use in cleaving nucleic acid molecules and inserting a nucleic acid molecule into the cleavage site; US 6,001,608, Methods of making an RNP particle having nucleotide integrase activity; US 6,027,895, Methods for cleaving DNA with nucleotide integrases; US 6,306,596, Methods for cleaving single-stranded and double-stranded DNA substrates with nucleotide integrases; US 7,592,161, Methods for analyzing the insertion capabilities of modified group II introns; and US PRO 61/812,914, Targetron system for efficient gene targeting in thermophiles, plus international filings of the above patents. The above patents and patent applications are licensed by the Ohio State University and the University of Texas to InGex, LLC, which sublicenses targetron technology to others for commercial applications. GM, AML, the Ohio State University, and the University of Texas are minority equity holders in InGex, LLC, and AML serves as an advisor to InGex, LLC. The authors may receive royalty payments for commercial use of the technology. The materials described in this manuscript are freely available for the purpose of academic, non-commercial research under a Material Transfer Agreement from InGex, LLC. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: GM YY QC YJL AML. Performed the experiments: GM WH JZ GZC. Analyzed the data: GM YJL AML. Contributed reagents/materials/analysis tools: YY. Wrote the paper: GM YJL AML.