Methylation of the Claudin 1 Promoter Is Associated with Loss of Expression in Estrogen Receptor Positive Breast Cancer

Francescopaolo Di Cello; Leslie Cope; Huili Li; Jana Jeschke; Wei Wang; Stephen B. Baylin; Cynthia A. Zahnow

doi:10.1371/journal.pone.0068630

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Open Access

Peer-reviewed

Research Article

Methylation of the Claudin 1 Promoter Is Associated with Loss of Expression in Estrogen Receptor Positive Breast Cancer

Francescopaolo Di Cello,

Affiliation Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Leslie Cope,

Affiliation Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Huili Li,

Affiliation Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Jana Jeschke,

Affiliation Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Wei Wang,

Affiliation Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Stephen B. Baylin,

Affiliation Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Cynthia A. Zahnow

Affiliation Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯

Methylation of the Claudin 1 Promoter Is Associated with Loss of Expression in Estrogen Receptor Positive Breast Cancer

Francescopaolo Di Cello,
Leslie Cope,
Huili Li,
Jana Jeschke,
Wei Wang,
Stephen B. Baylin,
Cynthia A. Zahnow

Published: July 3, 2013
https://doi.org/10.1371/journal.pone.0068630

About the Authors

Francescopaolo Di Cello: Affiliation Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Leslie Cope: Affiliation Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Huili Li: Affiliation Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Jana Jeschke: Affiliation Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Wei Wang: Affiliation Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Stephen B. Baylin: Affiliation Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Cynthia A. Zahnow: Affiliation Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FDC LC SBB CAZ. Performed the experiments: FDC HL JJ. Analyzed the data: FDC LC HL JJ WW. Wrote the manuscript: FDC CAZ.

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DNA methylation
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Breast cancer
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Gene expression
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Cancer treatment
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Microarrays
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Gastric cancer
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Epigenetic therapy
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Thyroid carcinoma
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