About the Authors

Gurli Baer

Contributed equally to this work with: Gurli Baer, Philipp Baumann

Affiliation Department of Pediatrics, University Basel, Basel, Switzerland

Philipp Baumann

Contributed equally to this work with: Gurli Baer, Philipp Baumann

Affiliation University Children's Hospital Basel, Basel, Switzerland

Michael Buettcher

Affiliation Department of Pediatrics, Kantonsspital Aarau, Aarau, Switzerland

Ulrich Heininger

Affiliations Department of Pediatrics, University Basel, Basel, Switzerland, University Children's Hospital Basel, Basel, Switzerland

Gerald Berthet

Affiliation Department of Pediatrics, Kantonsspital Aarau, Aarau, Switzerland

Juliane Schäfer

Affiliation Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland

Heiner C. Bucher

Affiliation Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland

Daniel Trachsel

Affiliations Department of Pediatrics, University Basel, Basel, Switzerland, University Children's Hospital Basel, Basel, Switzerland

Jacques Schneider

Affiliations Department of Pediatrics, University Basel, Basel, Switzerland, University Children's Hospital Basel, Basel, Switzerland

Muriel Gambon

Affiliation University Children's Hospital Basel, Basel, Switzerland

Diana Reppucci

Affiliation University Children's Hospital Basel, Basel, Switzerland

Jessica M. Bonhoeffer

Affiliation University Children's Hospital Basel, Basel, Switzerland

Jody Stähelin-Massik

Affiliation Department of Pediatrics, Kantonsspital Aarau, Aarau, Switzerland

Philipp Schuetz

Affiliation Department of Internal Medicine, University Hospital Basel, Basel, Switzerland

Beat Mueller

Affiliation Department of Internal Medicine, Kantonsspital Aarau, Basel, Switzerland

Gabor Szinnai

Affiliations Department of Pediatrics, University Basel, Basel, Switzerland, University Children's Hospital Basel, Basel, Switzerland

Urs B. Schaad

Affiliations Department of Pediatrics, University Basel, Basel, Switzerland, University Children's Hospital Basel, Basel, Switzerland

Jan Bonhoeffer

jan.bonhoeffer@ukbb.ch

Affiliations Department of Pediatrics, University Basel, Basel, Switzerland, University Children's Hospital Basel, Basel, Switzerland

Competing Interests

HCB received an unrestricted research grant from B.R.A.H.M.S. unrelated to this study. PS has received support from B.R.A.H.M.S. and Biomerieux to attend meetings and fulfill speaking engagements unrelated to this study. BM served as a consultant and received research support from B.R.A.H.M.S. and BioMerieux. All other authors have no conflict of interest. No commercial sponsor had any involvement in design and conduct of the study, namely collection, management, analysis, and interpretation of the data; and preparation, decision to submit, review, or approval of the manuscript. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: G. Baer PB UH G. Berthet HCB DT J. Schneider JSM PS BM GS UBS JB. Performed the experiments: G. Baer PB MB UH G. Berthet DT J. Schneider MG DR JMB JSM GS JB. Analyzed the data: G. Baer PB J. Schäfer HCB DT JS JSM PS JB. Contributed reagents/materials/analysis tools: UH G. Berthet J. Schäfer HCB DT J. Schneider PS BM UBS. Wrote the manuscript: G. Baer PB MB UH G. Berthet J. Schäfer HCB DT J. Schneider MG DR JMB JSM PS BM GS UBS JB.