About the Authors
- Cecile M. Krejsa
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Affiliation Department of Pre-clinical Development, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Rick D. Holly
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Affiliation Department of Research, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Mark Heipel
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Affiliation Department of Research, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Ken M. Bannink
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Affiliation Department of Pre-clinical Development, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Rebecca Johnson
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Affiliation Department of Research, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Richard Roque
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Affiliation Department of Pre-clinical Development, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Jane Heffernan
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Affiliation Department of Pre-clinical Development, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Julie Hill
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Affiliation Department of Pre-clinical Development, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Lay Chin
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Affiliation Department of Pre-clinical Development, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Felecia Wagener
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Affiliation Department of Pre-clinical Development, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Faith Shiota
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Affiliation Department of Research, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Katherine Henderson
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Affiliation Department of Research, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Pallavur V. Sivakumar
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Affiliation Department of Research, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Hong-Ping Ren
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Affiliation Department of Pre-clinical Development, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Fariba Barahmand-pour
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Affiliation Department of Research, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Don Foster
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Affiliation Department of Research, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Chris Clegg
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Affiliation Department of Research, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Wayne Kindsvogel
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Affiliation Department of Research, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Rafael Ponce
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Affiliation Department of Pre-clinical Development, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Steven D. Hughes
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Affiliation Department of Pre-clinical Development, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
- Kim Waggie
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* E-mail: Kim.Waggie@bms.com
Affiliation Department of Pre-clinical Development, ZymoGenetics, Incorporated, a Bristol-Myers Squibb Company, Seattle, Washington, United States of America
Competing Interests
The authors have read the journal’s policy and have the following conflicts: at the time this research was conducted all the authors were employees of ZymoGenetics, Inc., the commercial funder of the research. However, this does not alter the authors’ adherence to all PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: CK RH J. Hill PS DF CC WK RP SH. Performed the experiments: MH KB RJ RR J. Heffernan LC FW FS KH HR FB KW. Analyzed the data: CK RH J. Hill PS DF CC WK RP SH MH KB RJ RR J. Heffernan LC FW FS KH HR FB KW. Wrote the paper: CK RH PS WK SH KW.