About the Authors
- Matthew J. Cooper
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Affiliations Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Curriculum in Genetics & Molecular Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Nathan J. Cox
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Affiliation Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Eric I. Zimmerman
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Affiliation Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Brian J. Dewar
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Affiliation Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America
- James S. Duncan
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Affiliation Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Martin C. Whittle
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Affiliation Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Thien A. Nguyen
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Affiliation Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Lauren S. Jones
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Affiliation Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Sreerupa Ghose Roy
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Affiliation Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America
- David M. Smalley
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Affiliation Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Pei Fen Kuan
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Affiliations Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Kristy L. Richards
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Affiliations Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Division of Hematology & Oncology, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Richard I. Christopherson
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Affiliation School of Molecular Bioscience, University of Sydney, Sydney, New South Wales, Australia
- Jian Jin
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Affiliation Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Stephen V. Frye
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Affiliation Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Gary L. Johnson
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Affiliations Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Albert S. Baldwin
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Affiliations Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Curriculum in Genetics & Molecular Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Lee M. Graves
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* E-mail: lmg@med.unc.edu
Affiliations Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America
Competing Interests
We would like to declare that one of the co-authors of this manuscript, Kristy L. Richards, is a PLOS ONE Editorial Board member. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: MJC EIZ JSD MCW GLJ ASB LMG. Performed the experiments: MJC NJC EIZ BJD JSD MCW TAN LSJ SGR. Analyzed the data: MJC NJC EIZ DMS PFK. Contributed reagents/materials/analysis tools: DMS KLR RIC JJ SVF GLJ ASB LMG. Wrote the paper: MJC LMG.