About the Authors
- Han-Pil Choi
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Affiliation Dept of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America
- Silvia Juarez
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Affiliation Proteomic Facility, CNB-National Centre for Biotechnology, CSIC, Darwin 3, Madrid, Spain
- Sergio Ciordia
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Affiliation Proteomic Facility, CNB-National Centre for Biotechnology, CSIC, Darwin 3, Madrid, Spain
- Marisol Fernandez
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Affiliation Proteomic Facility, CNB-National Centre for Biotechnology, CSIC, Darwin 3, Madrid, Spain
- Rafael Bargiela
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Affiliation Spanish National Research Council (CSIC), Institute of Catalysis, Madrid, Spain
- Juan P. Albar
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Affiliation Proteomic Facility, CNB-National Centre for Biotechnology, CSIC, Darwin 3, Madrid, Spain
- Varun Mazumdar
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Affiliation Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America
- Brian P. Anton
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Affiliation New England Biolabs, Ipswich, Massachusetts, United States of America
- Simon Kasif
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Affiliations Dept of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America, Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America
- Manuel Ferrer
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* E-mail: steffen@bu.edu (MS); mferrer@icp.csic.es (MF)
Affiliation Spanish National Research Council (CSIC), Institute of Catalysis, Madrid, Spain
- Martin Steffen
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* E-mail: steffen@bu.edu (MS); mferrer@icp.csic.es (MF)
Affiliations Dept of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America, Dept of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
Competing Interests
Author Brian P Anton is an employee of New England Biolabs. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: MS M. Ferrer. Performed the experiments: HPC SJ SC MF RB JPA. Analyzed the data: HPC SJ SC MF RB JPA M. Ferrer MS VM. Wrote the paper: MS M. Ferrer. Performed the experiments on recombinant protein: HPC MS. Performed the experiments on native protein: SJ SC M. Fernandez RB JPA. Provided oversight of the informatics database used to derive the protein clusters and sequence homology for the studied proteins: SK BA. Contributed the conceptual implementation of COMBREX: SK MS.