About the Authors

Takeru Yoshimura

Contributed equally to this work with: Takeru Yoshimura, Ofra Benny

Affiliation Department of Surgery, Vascular Biology Program, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Ofra Benny

Contributed equally to this work with: Takeru Yoshimura, Ofra Benny

ofra.bennyratsaby@childrens.harvard.edu

Affiliation Department of Surgery, Vascular Biology Program, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Lauren Bazinet

Affiliation Department of Surgery, Vascular Biology Program, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Robert J. D’Amato

Affiliations Department of Surgery, Vascular Biology Program, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

As the authors have declared, a patent was filed based on this and previous studies (“Metap-2 inhibitor polymersomes for therapeutic administration”. Children'S Medical Center Jun, 24 2010: US 20100158855). The patent application covers the invention of using nanomicells with MetAp2 inhibitor for treating inflammation related disease and disorders such as an autoimmune disease (including uveitis). The authors confirm that this patent does not alter their adherence to all the PLOS ONE policies on sharing data and materials, as detailed online.

Author Contributions

Conceived and designed the experiments: TY OB LB RD. Performed the experiments: TY OB LB. Analyzed the data: TY OB RD. Contributed reagents/materials/analysis tools: RD. Wrote the paper: TY OB LB.