About the Authors

Yasuhiro Kawano

Affiliations Department of Molecular and Medical Genetics, Oregon Health and Science University School of Medicine, Portland, Oregon, United States of America, Takara Bio Inc., Otsu Shiga, Japan

Shane Neeley

Affiliation Department of Molecular and Medical Genetics, Oregon Health and Science University School of Medicine, Portland, Oregon, United States of America

Kei Adachi

Affiliation Department of Molecular and Medical Genetics, Oregon Health and Science University School of Medicine, Portland, Oregon, United States of America

Hiroyuki Nakai

nakaih@ohsu.edu

Affiliation Department of Molecular and Medical Genetics, Oregon Health and Science University School of Medicine, Portland, Oregon, United States of America

Competing Interests

The authors have the following inerests: This project was in part supported by a sponsored research fund obtained from Takara Bio Inc. Co-author Yasuhiro Kawano is an employee of Takara Bio Inc. The authors confirm that this does not alter their adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HN. Performed the experiments: YK SN KA HN. Analyzed the data: YK SN HN. Wrote the paper: HN.