About the Authors

Myles Horton

Affiliation Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

Jayesh Modi

Affiliation Department of Radiology, University of Calgary, Calgary, Alberta, Canada

Shiel K. Patel

Affiliation Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

Andrew M. Demchuk

Affiliations Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada, Department of Radiology, University of Calgary, Calgary, Alberta, Canada, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada

Mayank Goyal

Affiliations Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada, Department of Radiology, University of Calgary, Calgary, Alberta, Canada, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada

Michael D. Hill

Affiliations Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada, Department of Radiology, University of Calgary, Calgary, Alberta, Canada, Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada, Department of Medicine, University of Calgary, Calgary, Alberta, Canada, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada

Shelagh B. Coutts

scoutts@ucalgary.ca

Affiliations Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada, Department of Radiology, University of Calgary, Calgary, Alberta, Canada, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada

Competing Interests

S.B.C. received salary support from the Heart and Stroke Foundation of Canada’s Distinguished Clinician Scientist award, supported in partnership with the Canadian Institute of Health Research (CIHR), Institute of Circulatory and Respiratory Health and AstraZeneca Canada Inc. Funding sources consisted of a Pfizer Cardiovascular research award. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: SBC MG. Performed the experiments: JM SP. Analyzed the data: SBC MH. Contributed reagents/materials/analysis tools: SP JM MG. Wrote the paper: MH SBC. Contributions to conception and design as well as analysis and interpretation of data: MDH AMD.