Clinical Significance in Oral Cavity Squamous Cell Carcinoma of Pathogenic Somatic Mitochondrial Mutations

Chih-Hsiung Lai; Shiang-Fu Huang; Chun-Ta Liao; I-How Chen; Hung-Ming Wang; Ling-Ling Hsieh

doi:10.1371/journal.pone.0065578

Loading metrics

Open Access

Peer-reviewed

Research Article

Clinical Significance in Oral Cavity Squamous Cell Carcinoma of Pathogenic Somatic Mitochondrial Mutations

Chih-Hsiung Lai,

Affiliation Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan
⨯
Shiang-Fu Huang,

Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan
⨯
Chun-Ta Liao,

Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan
⨯
I-How Chen,

Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan
⨯
Hung-Ming Wang,

Affiliation Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan
⨯
Ling-Ling Hsieh

* E-mail: llhsieh@mail.cgu.edu.tw

Affiliation Department of Public Health, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan
⨯

Clinical Significance in Oral Cavity Squamous Cell Carcinoma of Pathogenic Somatic Mitochondrial Mutations

Chih-Hsiung Lai,
Shiang-Fu Huang,
Chun-Ta Liao,
I-How Chen,
Hung-Ming Wang,
Ling-Ling Hsieh

Published: June 14, 2013
https://doi.org/10.1371/journal.pone.0065578

About the Authors

Chih-Hsiung Lai

Affiliation Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan

Shiang-Fu Huang

Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan

Chun-Ta Liao

Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan

I-How Chen

Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan

Hung-Ming Wang

Affiliation Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan

Ling-Ling Hsieh

* E-mail: llhsieh@mail.cgu.edu.tw

Affiliation Department of Public Health, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CHL LLH. Performed the experiments: CHL. Analyzed the data: CHL SFH LLH. Contributed reagents/materials/analysis tools: SFH CTL IHC HMW LLH. Wrote the paper: CHL SFH LLH.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mitochondrial DNA
Is the Subject Area "Mitochondrial DNA" applicable to this article?

Thanks for your feedback.
Somatic mutation
Is the Subject Area "Somatic mutation" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Substitution mutation
Is the Subject Area "Substitution mutation" applicable to this article?

Thanks for your feedback.
Head and neck cancers
Is the Subject Area "Head and neck cancers" applicable to this article?

Thanks for your feedback.
Nonsense mutation
Is the Subject Area "Nonsense mutation" applicable to this article?

Thanks for your feedback.
Mutation
Is the Subject Area "Mutation" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.