Differential Mechanisms of Activation of the Ang Peptide Receptors AT1, AT2, and MAS: Using In Silico Techniques to Differentiate the Three Receptors

Jeremy W. Prokop; Robson A. S. Santos; Amy Milsted

doi:10.1371/journal.pone.0065307

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Open Access

Peer-reviewed

Research Article

Differential Mechanisms of Activation of the Ang Peptide Receptors AT1, AT2, and MAS: Using In Silico Techniques to Differentiate the Three Receptors

Jeremy W. Prokop,

Affiliation Department of Biology, Program in Integrated Bioscience, The University of Akron, Akron, Ohio, United States of America
⨯
Robson A. S. Santos,

Affiliation Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
⨯
Amy Milsted

* E-mail: milsted@uakron.edu

Affiliation Department of Biology, Program in Integrated Bioscience, The University of Akron, Akron, Ohio, United States of America
⨯

Differential Mechanisms of Activation of the Ang Peptide Receptors AT1, AT2, and MAS: Using In Silico Techniques to Differentiate the Three Receptors

Jeremy W. Prokop,
Robson A. S. Santos,
Amy Milsted

Published: June 3, 2013
https://doi.org/10.1371/journal.pone.0065307

About the Authors

Jeremy W. Prokop

Affiliation Department of Biology, Program in Integrated Bioscience, The University of Akron, Akron, Ohio, United States of America

Robson A. S. Santos

Affiliation Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

Amy Milsted

* E-mail: milsted@uakron.edu

Affiliation Department of Biology, Program in Integrated Bioscience, The University of Akron, Akron, Ohio, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JWP RASS AM. Performed the experiments: JWP. Analyzed the data: JWP RASS AM. Contributed reagents/materials/analysis tools: JWP RASS AM. Wrote the paper: JWP.

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Biochemical simulations
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Sequence alignment
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G protein coupled receptors
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Protein sequencing
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Molecular dynamics
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Renin-angiotensin system
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Lipid structure
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Protein structure comparison
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