About the Authors

Chao Zhang

Affiliation Roche Research and Early Development China, Shanghai, China

Xihan Wu

Affiliation Roche Research and Early Development China, Shanghai, China

Meifang Zhang

Affiliation Roche Research and Early Development China, Shanghai, China

Liangcheng Zhu

Affiliation Roche Research and Early Development China, Shanghai, China

Rong Zhao

Affiliation Roche Research and Early Development China, Shanghai, China

Danqing Xu

Affiliation Roche Research and Early Development China, Shanghai, China

Zhaohu Lin

Affiliation Roche Research and Early Development China, Shanghai, China

Chungen Liang

Affiliation Roche Research and Early Development China, Shanghai, China

Taiping Chen

Affiliation Crown Bioscience Inc. Beijing, China

Li Chen

Affiliation Roche Research and Early Development China, Shanghai, China

Yi Ren

Affiliation Roche Research and Early Development China, Shanghai, China

Joe Zhang

Affiliation Roche Research and Early Development China, Shanghai, China

Ning Qin

Affiliation Roche Research and Early Development China, Shanghai, China

Xiongwen Zhang

xwzhang@sat.ecnu.edu.cn

Affiliation Roche Research and Early Development China, Shanghai, China

Competing Interests

All authors are employees or previous employees of Roche R&D Center (China) except Taiping Chen, who is an employee of a CRO company named Crown Bioscience Inc. Beijing, China. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CZ XW XZ LC YR JZ NQ TC. Performed the experiments: CZ MZ LZ RZ DX ZL CL. Analyzed the data: CZ DX LZ. Contributed reagents/materials/analysis tools: CZ DX. Wrote the paper: CZ XZ.