About the Authors

Mikael Bjursell

mikael.bjursell@astrazeneca.com

Affiliation AstraZeneca R&D, Mölndal, Sweden

Marianne Wedin

Affiliation AstraZeneca R&D, Mölndal, Sweden

Therése Admyre

Affiliation AstraZeneca R&D, Mölndal, Sweden

Majlis Hermansson

Affiliation AstraZeneca R&D, Mölndal, Sweden

Gerhard Böttcher

Affiliation AstraZeneca R&D, Mölndal, Sweden

Melker Göransson

Affiliation AstraZeneca R&D, Mölndal, Sweden

Daniel Lindén

Affiliation AstraZeneca R&D, Mölndal, Sweden

Krister Bamberg

Affiliation AstraZeneca R&D, Mölndal, Sweden

Jan Oscarsson

Affiliation AstraZeneca R&D, Mölndal, Sweden

Mohammad Bohlooly-Y

Affiliation AstraZeneca R&D, Mölndal, Sweden

Competing Interests

This study was funded by AstraZeneca, the employer of Mikael Bjursell, Marianne Wedin, Therése Admyre, Majlis Hermansson, Gerhard Böttcher, Melker Göransson, Daniel Linden, Krister Bamberg, Jan Oscarsson, Mohammad Bohlooly-Y. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: MB MW TA GB MG DL KB MB-Y. Performed the experiments: MB MW TA MH GB MG DL KB JO MB-Y. Analyzed the data: MB TA MH GB MG DL KB JO MB-Y. Contributed reagents/materials/analysis tools: MB MW TA MH GB MG. Wrote the paper: MB DL KB JO MB-Y.